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更新于 2025-06-12 00:03:22

DMPK Senior Scientist

2-2.5萬(wàn)
  • 北京昌平區(qū)
  • 1-3年
  • 博士
  • 全職
  • 招1人

職位描述

藥物合成藥物分析藥理研究化學(xué)藥生物藥新藥
We are seeking a highly motivated and experienced Senior Scientist to join our DMPK (Drug Metabolism and Pharmacokinetics) team. The successful candidate will play a key role in designing, executing, and interpreting DMPK studies to support drug discovery and development programs. Contribute to the optimization and prioritization of drug candidates by evaluating their ADME (Absorption, Distribution, Metabolism, Excretion) properties and pharmacokinetics (PK) to advance our pipeline. Areas of Responsibilities 1. Design, protocol review, implementation, data analysis, and report of preclinical pharmacokinetic studies, and supporting the project team in candidate drug selection. 2. Responsible for drug ADME properties assessment, such as liver microsome stability, protein binding, CYPs inhibition/induction, drug transporters (P-gP/BCRP/OATP, etc), or other routine assays. 3. Develop and validate bioanalysis of small molecules and biomarkers to support clinical studies. 4. Responsible for the daily maintenance of LC/MS/MS instruments and SOP updates, or other tasks assigned by the superior. 5. Work effectively in a cross-functional team environment (Chemistry, Pharmacology, Biomarker, etc), and interact with different levels within the organization as well as CROs/vendors/academic institutuions. Qualification Required 1. Ph.D. degree in Pharmaceutical Sciences, Analytical Chemistry, Chemistry, or related field required with 0-3 years of related working experience. 2. Basic knowledge of drug ADME & PK properties, familiarity with the whole process of drug discovery and development, and relevant regulations is preferred. 3. Strong literature retrieval and English literature reading ability, good English listening, speaking, reading, and writing skills. 4. Good communication skills, strong innovation and learning ability, and capable of challenging work.

工作地點(diǎn)

玉河南路(中關(guān)村生命科學(xué)園)北京市昌平區(qū)生命科學(xué)園醫(yī)科路9號(hào)院2號(hào)樓9層

職位發(fā)布者

劉薇/HR

昨日活躍
立即溝通
公司Logo維泰瑞隆
維泰瑞?。ū本┥锟萍加邢薰臼且患胰蛐缘膶?zhuān)注于研發(fā)First-in-class化學(xué)藥物的生物制藥公司。該公司由北京生命科學(xué)研究所的所長(zhǎng),美國(guó)科學(xué)院院士,中國(guó)科學(xué)院外籍院士王曉東博士和北京生命科學(xué)研究所資深研究員張志遠(yuǎn)博士共同創(chuàng)建。公司坐落在昌平區(qū)中關(guān)村生命科學(xué)園。本公司針對(duì)王曉東博士在細(xì)胞凋亡、細(xì)胞程序性壞死等多種細(xì)胞死亡領(lǐng)域的原創(chuàng)性發(fā)現(xiàn)研發(fā)小分子抑制劑,致力于多種重大疾病的治療。這些抑制劑針對(duì)的疾病包括神經(jīng)退行性疾病如阿爾茲海默癥、多發(fā)性硬化癥、帕金森病等;缺血性疾病如腦卒中、腎缺血、心肌缺血;以及炎癥性疾病如腸炎、銀屑病、膿毒癥等。本公司研發(fā)能力涵蓋小分子篩選,化學(xué)合成,分子、細(xì)胞生物學(xué)研究,動(dòng)物藥效評(píng)價(jià),藥代藥動(dòng)分析及臨床前預(yù)毒理分析等藥物研發(fā)的所有環(huán)節(jié)。本公司的研發(fā)團(tuán)隊(duì)由王曉東博士和張志遠(yuǎn)博士直接領(lǐng)導(dǎo),團(tuán)隊(duì)主要成員均具備十年以上科學(xué)研究經(jīng)驗(yàn),前期科研成果均發(fā)表在國(guó)際頂級(jí)學(xué)術(shù)刊物如,Cell,Molecular Cell, eLife,PNAS等。本公司的管理團(tuán)隊(duì)均具備數(shù)十年國(guó)際制藥企業(yè)的管理經(jīng)驗(yàn),曾成功推動(dòng)多個(gè)藥物進(jìn)入臨床實(shí)驗(yàn)和上市使用。公司福利待遇:對(duì)于優(yōu)秀博士公司有機(jī)會(huì)解決北京戶口問(wèn)題;公司設(shè)有博士后工作站。
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